Change Determinants In PSA Over Time - Its Association With Recurrence After External Beam Radiation Therapy For Prostate Cancer In 5 Large Cohorts

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UroToday.com - In the November 1, 2008 issue of International Journal of Radiation Oncology, Biology, Physics, Dr. Cécile Proust-Lima and colleagues presented a linear mixed model to construct patient PSA profiles after radiotherapy (XRT) for prostate cancer (CaP). The included XRT data from 5 patient cohorts where men with CaP were treated for clinically localized disease. Two or 3-dimensional XRT was given to the prostate and seminal vesicles and whole-pelvic radiotherapy was not routinely performed. Prognostic factors evaluated included Gleason score, T-stage, pre-treatment initial PSA (iPSA), age and XRT dosage.